Pan-RAS-IN-2
Pan-rasin-2 (compound 6A) is a molecular glues that targets RAS. Pan-rasin-2 has significant inhibitory activity on cell proliferation of RAS mutant cell lines. Pan-rasin-2 can form ternary complexes with cyclophilin A (CYPA) and RAS (ON) proteins and the formation of ternary complexes can block the binding of RAF downstream of RAS, which has anti-tumor effects[1].
Product Specifications
CAS Number
3034673-92-9
UNSPSC
12352005
Target
Cyclophilin; Molecular Glues; Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pan-ras-in-2.html
Purity
98.00
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
Molecular Formula
C46H60N8O5S
Molecular Weight
837.08
References & Citations
[1]Y Zhang, et al. Macrocyclic derivative and use thereof. WO2024067857A1. 2023-09-28
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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