Pan-RAS-IN-2

Pan-rasin-2 (compound 6A) is a molecular glues that targets RAS. Pan-rasin-2 has significant inhibitory activity on cell proliferation of RAS mutant cell lines. Pan-rasin-2 can form ternary complexes with cyclophilin A (CYPA) and RAS (ON) proteins and the formation of ternary complexes can block the binding of RAF downstream of RAS, which has anti-tumor effects[1].

Product Specifications

CAS Number

[3034673-92-9]

UNSPSC

12352005

Target

Cyclophilin; Molecular Glues; Ras

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; MAPK/ERK Pathway; PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pan-ras-in-2.html

Purity

98.00

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1OCC(C)(CC2=[C@@]([C@@]3=C([C@H](C)OC)N=CC(N4CCN(C)CC4)=C3)N(CC)C5=CC=C(C6=CSC(C[C@H](NC([C@H]7[C@H](C)[C@@H]7C)=O)C(N8N[C@H]1C9CC8C9)=O)=N6)C=C25)C