Rp-8-Br-PET-cGMPS (sodium)
Rp-8-Br-PET-cGMPS sodium (Rp-8-Bromo-PET-cGMPS) is an analog of cyclic GMP (cGMP) . It is a cell permeable, competitive, and reversible inhibitor of cGMP-dependent protein kinases (cGKs) that blocks activation of cGKI and cGKII by cGMP (Kis=35 and 30 nM) . It less potently inhibits protein kinase A (Ki=11 μM) and cGMP-induced activation of cyclic nucleotide-gated channels (IC50=25 μM) . In the absence of cGMP stimulation, Rp-8-bromo-PET-cGMPS can act as a partial agonist of cGKI (Ki=1 μM) . Rp-8-bromo-PET-cGMPS is resistant to hydrolysis by phosphodiesterase 11.
Product Specifications
CAS Number
[185246-32-6]
Product Name Alternative
Rp-8-Bromo-PET-cGMPS
UNSPSC
12352005
Target
PKG
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/rp-8-br-pet-cgmps-sodium.html
Purity
99.4
Smiles
BrC1=NC2=C(NC3=NC(C4=CC=CC=C4)=CN3C2=O)N1[C@@](O[C@@](CO5)([H])[C@@]6([H])O[P@@]5(S[Na])=O)([H])[C@@H]6O.[R]
Molecular Formula
C18H14BrN5NaO6PS
Molecular Weight
562.27
References & Citations
[1]Jäger, et al. Activation of PDE10 and PDE11 phosphodiesterases. J. Biol. Chem. 287 (2), 1210-1219 (2012) .
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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