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Anti-Factor XII Light Chain Antibody

Mouse Monoclonal Antibody specific to Factor XII Light Chain

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

EC 3.4.21.38, Hageman factor, HAF [Cleaved into: Coagulation factor XIIa heavy chain; Beta-factor XIIa part 1; Coagulation factor XIIa light chain

Gene Name

F12

NCBI Gene ID

<a href="https://www.ncbi.nlm.nih.gov/gene/?term=F12">F12</a>

UniProt

P00748

Cellular Locus

Secreted.

Host

Mouse

Reactivity

Human

Immunogen

Purified human Factor XII.

Target Antigen

Coagulation factor XII

Target

Factor XII Light Chain

Clonality

Monoclonal

Isotype

IgG1

Type

Antibody

Applications

ELISA, Coagulation Assays

Field of Research

Coagulation factors.

Purification Method

Purified by Protein G affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. {PubMed:21304106}.

Additionnal Information

This antibody may be used in ELISA to detect/quantitate Factor XII and in coagulation assays. Other applications are under investigation.

Storage Conditions

These antibodies are stable for at least one (1) year at -20°C to -70°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.

Specificity

Purified human Factor XII.

Formulation

PBS, pH 7.4.

Buffer pH

pH 7.4

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