BMS-986308

BMS-986308 is a selective and orally active renal outer medullary potassium (ROMK) channel inhibitor. BMS-986308 is selective for ROMK over hERG. BMS-986308 can be used for heart failure research[1].

Product Specifications

CAS Number

[2254333-97-4]

UNSPSC

12352005

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/bms-986308.html

Smiles

CC1=C(COC2=O)C2=CC=C1[C@@H]3CN(C[C@@H](N3)C)CC4=NN(C5=CC(C)=C(C=N5)C#N)N=C4

Molecular Formula

C24H25N7O2

Molecular Weight

443.50

References & Citations

[1]Jeremy M Richter, et al. Discovery of BMS-986308: A Renal Outer Medullary Potassium Channel Inhibitor for the Treatment of Heart Failure. J Med Chem. 2024 Jun 13;67 (11) :9731-9744.