MLS-0053105

MLS-0053105, a chloromaleimide, is a selective BFL-1 inhibitor with an IC50 of 0.4 µM for Bfl-1/F-Bid. MLS-0053105 shows over 10 times less potent inhibition of Bcl-W, Bcl-2, and Bcl-XL and no activity against Bcl-B and Mcl-1[1].

Product Specifications

CAS Number

[370572-36-4]

UNSPSC

12352005

Target

Bcl-2 Family

Type

Reference compound

Related Pathways

Apoptosis

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mls-0053105.html

Smiles

O=C1C(Cl)=C(N2CCN(CC2)C)C(N1C3=CC=C(C(Cl)=C3)Cl)=O

Molecular Formula

C15H14Cl3N3O2

Molecular Weight

374.65

References & Citations

[1]Dayong Zhai, et al. High-throughput fluorescence polarization assay for chemical library screening against anti-apoptotic Bcl-2 family member Bfl-1. J Biomol Screen. 2012 Mar;17 (3) :350-60.