Anti-FBG3 Antibody

Rabbit Polyclonal Antibody specific to FBG3 (F Box 3)

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

F-box protein FBX30, F-box/G-domain protein 3

Gene Name

FBXO44

NCBI Gene ID

UniProt

Q9H4M3

Host

Rabbit

Reactivity

Human

Immunogen

Synthetic peptide corresponding to amino acids 103-119 (EWKVEDLSRDQRKEFPN) of human

Target Antigen

F-box only protein 44

Target

FBG3

Clonality

Polyclonal

Type

Antibody

Applications

WB, ELISA

Field of Research

Neuroscience

Purification Method

Purified by peptide immuno-affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Additionnal Information

Immunoblotting : use at 1:500 dilution. A band of approximately 31 kDa is detected. <br><br>Positive control: recombinant human FBG3.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.

Specificity

This antibody recognizes human FBG3 . Sequence homology to mouse and rat FBG3 is 94%.

Formulation

PBS, pH 7.4.

Buffer pH

pH 7.4

Target Background

F-box proteins, critical components of the conserved ubiquitin-protein ligase complex SCF (Skp1/Cdc53-Cullin1/F- box), recruit substrates for ubiquitination and consequent degradation through their specific protein-protein interaction domains. Novel human F-box proteins named FBG1, FBG2, FBG3, FBG4 and FBG5 constitute a subfamily of mammalian F-box proteins. FBG genes are expressed in a limited number of human tissues including kidney, liver, brain and muscle tissues.