Anti-Tumor Endothelial Marker 5 Antibody

Rabbit Polyclonal Antibody specific to Tumor Endothelial Marker 5

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

Anti-Tumor Endothelial Marker 5 Rabbit Polyclonal Antibody

Gene Name

TEM5

NCBI Gene ID

UniProt

Q6YN44

Host

Rabbit

Reactivity

Human

Immunogen

Synthetic peptide conjugated to KLH

Target Antigen

Tumor endothelial marker 5

Target

Tumor Endothelial Marker 5

Clonality

Polyclonal

Type

Antibody

Applications

IHC, IHC-P

Field of Research

Cancer research

Purification Method

Purified by immunogen affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Additionnal Information

<br><br>Immunohistochemistry: Use at 10 ug/ml.

Storage Conditions

This antibody is stable at 4°C (short- term) and -70°C (long-term).

Specificity

This antibody recognizes an epitope within the extracellular domain of human TEM5.

Formulation

PBS containing 0.1% sodium azide

Target Background

Tumor endothelial marker 5 (TEM5) is a member of the adhesion family of GPCRs and is upregulated in endothelial cells during tumor and physiologic angiogenesis. Soluble TEM5 (sTEM5) is shed by endothelial cells during angiogenesis and binds to glycosaminoglycans on extracellular matrix and cell surface proteoglycans. After proteolytic processing, an RGD- binding site for integrin alphavbeta3 is exposed on sTEM5. Adhesion of endothelial cells to immobilized proteolytically processed sTEM5 promotes their survival.