T-3364366
Product Specifications
UNSPSC Description
T-3364366 is a reversible, slow-binding, thienopyrimidinone delta-5 desaturase (D5D) inhibitor with IC50s of 1.9 nM and 2.1 nM in HepG2 and RLN-10 cells, respectively. T-3364366 exhibits potent D5D (IC500=19 nM) inhibitory activity and excellent selectivity away from delta-6 desaturase (D6D, IC50=6200 nM) and delta-9 desaturase (stearoyl-CoA desaturase, SCD,50 >10000 nM) in the enzymatic activity assay[1].
Target Antigen
Others
Type
Reference compound
Related Pathways
Others
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/t-3364366.html
Purity
99.73
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CC(NCCSC1=NC2=CSC=C2C(N1C3=CC=C(OCC(F)(F)F)C=C3)=O)=O
Molecular Weight
443.46
References & Citations
[1]Ikuo Miyahisa, et al. T-3364366 Targets the Desaturase Domain of Delta-5 Desaturase with Nanomolar Potency and a Multihour Residence Time. ACS Med Chem Lett. 2016 Aug 10;7(9):868-72.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-124346/T-3364366-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-124346/T-3364366-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1356354-09-0
Available Sizes
Curated Selection
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