T-3364366

T-3364366 is a reversible, slow-binding, thienopyrimidinone delta-5 desaturase (D5D) inhibitor with IC50s of 1.9 nM and 2.1 nM in HepG2 and RLN-10 cells, respectively. T-3364366 exhibits potent D5D (IC500=19 nM) inhibitory activity and excellent selectivity away from delta-6 desaturase (D6D, IC50=6200 nM) and delta-9 desaturase (stearoyl-CoA desaturase, SCD,50 >10000 nM) in the enzymatic activity assay[1].

Product Specifications

CAS Number

[1356354-09-0]

UNSPSC

12352005

Target

Stearoyl-CoA Desaturase (SCD)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/t-3364366.html

Purity

99.80

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

CC(NCCSC1=NC2=CSC=C2C(N1C3=CC=C(OCC(F)(F)F)C=C3)=O)=O

Molecular Formula

C18H16F3N3O3S2

Molecular Weight

443.46

References & Citations

[1]Ikuo Miyahisa, et al. T-3364366 Targets the Desaturase Domain of Delta-5 Desaturase with Nanomolar Potency and a Multihour Residence Time. ACS Med Chem Lett. 2016 Aug 10;7 (9) :868-72.