GSK926
GSK926 (compound 3) is a selective histone lysine methyltransferase EZH2 inhibitor (IC50=0.02 μM; Ki=7.9 nM), with SAM-competitive and cell-active properties. GSK926 can be used in cancer research[1].
Product Specifications
CAS Number
1346704-13-9
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gsk926.html
Smiles
O=C(C1=CC(C2=CC=C(N3CCN(CC3)C)N=C2)=CC4=C1C=NN4C(C)C)NCC5=C(C)C=C(C)NC5=O
Molecular Formula
C29H35N7O2
Molecular Weight
513.63
References & Citations
[1]Verma S K, et al. Identification of potent, selective, cell-active inhibitors of the histone lysine methyltransferase EZH2[J]. ACS medicinal chemistry letters, 2012, 3 (12) : 1091-1096.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EZH2
Frequently Asked Questions
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