PI3K/Akt/mTOR-IN-5

PI3K/Akt/mTOR-IN-5 (compound D3) is a derivative of Pseudolaric Acid B (HY-N6939) with anti-tumor activity. PI3K/Akt/mTOR-IN-5 inhibits excessive proliferation of tumor cells through the PI3K/AKT/mTOR and STAT3/GPX4 pathways. PI3K/Akt/mTOR-IN-5 effectively inhibits EDU positivity, reduces colony formation, places HCT-116 cells in the S phase and G2/M phase, and induces apoptosis[1].

Product Specifications

UNSPSC

12352005

Target

Akt; Apoptosis; mTOR; PI3K; STAT

Type

Reference compound

Related Pathways

Apoptosis; JAK/STAT Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pi3k-akt-mtor-in-5.html

Smiles

O=C(C1=CC[C@@]([C@@](CC1)(OC(C)=O)[C@]2([H])[C@](/C=C/C=C(C)/C(NCCN3CCCCC3)=O)(C)O4)(CC2)C4=O)OC

Molecular Formula

C30H42N2O7

Molecular Weight

542.66

References & Citations

[1]Qian Xu, et al. "Design, synthesis, and in vivo and in vitro biological screening of pseudolaric acid B derivatives as potential anti-tumor agents." Bioorganic Chemistry (2024) : 107670.