PI3K/Akt/mTOR-IN-5
Product Specifications
UNSPSC Description
PI3K/Akt/mTOR-IN-5 (compound D3) is a derivative of Pseudolaric Acid B (HY-N6939) with anti-tumor activity. PI3K/Akt/mTOR-IN-5 inhibits excessive proliferation of tumor cells through the PI3K/AKT/mTOR and STAT3/GPX4 pathways. PI3K/Akt/mTOR-IN-5 effectively inhibits EDU positivity, reduces colony formation, places HCT-116 cells in the S phase and G2/M phase, and induces apoptosis[1].
Target Antigen
Akt; Apoptosis; mTOR; PI3K; STAT
Type
Reference compound
Related Pathways
Apoptosis;JAK/STAT Signaling;PI3K/Akt/mTOR;Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pi3k-akt-mtor-in-5.html
Smiles
O=C(C1=CC[C@@]([C@@](CC1)(OC(C)=O)[C@]2([H])[C@](/C=C/C=C(C)/C(NCCN3CCCCC3)=O)(C)O4)(CC2)C4=O)OC
Molecular Weight
542.66
References & Citations
[1]Qian Xu, et al. "Design, synthesis, and in vivo and in vitro biological screening of pseudolaric acid B derivatives as potential anti-tumor agents." Bioorganic Chemistry (2024): 107670.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-159517/PI3K-Akt-mTOR-IN-5-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-159517/
Clinical Information
No Development Reported
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