Rhamnetin

Rhamnetin is a quercetin derivative found in Coriandrum sativum, inhibits secretory phospholipase A2 and histone deacetylase 2 (HDAC2) . Rhamnetin exhibits antitumor, antioxidant and anti-inflammatory activity[1][2].

Product Specifications

CAS Number

[90-19-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; HDAC; Phospholipase

Type

Natural Products

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/rhamnetin.html

Purity

99.18

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

OC1=C(C2=CC=C(O)C(O)=C2)OC3=C(C(O)=CC(OC)=C3)C1=O

Molecular Formula

C16H12O7

Molecular Weight

316.27

Precautions

H302, H315, H319, H335

References & Citations

[1]Novo Belchor M, et al. Evaluation of Rhamnetin as an Inhibitor of the Pharmacological Effect of Secretory Phospholipase A2. Molecules. 2017 Aug 31;22 (9) .|[2]Bharadwaj KK, et al., Rhamnetin, a nutraceutical flavonoid arrests cell cycle progression of human ovarian cancer (SKOV3) cells by inhibiting the histone deacetylase 2 protein. J Biomol Struct Dyn. 2024;42 (24) :13421-13436.|[3]Zhang W, et al., Rhamnetin attenuates cognitive deficit and inhibits hippocampal inflammatory response and oxidative stress in rats with traumatic brain injury. Cent Eur J Immunol. 2015;40 (1) :35-41.