Ponsegromab Antibody
Ponsegromab is a humanized monoclonal antibody that selectively inhibits GDF15 by blocking its interaction with the GFRAL receptor. This mechanism disrupts the associated signaling pathway, offering a potential therapeutic strategy for cancer-associated anorexia and cachexia, as investigated in preclinical research models.
Product Specifications
Product Name Alternative
Smad, TGF-beta/Smad, TGFbeta/Smad, TGF-beta, TGFbeta, TGF-b/Smad, TGFb, TGF-β/Smad, TGFβ, Ponsegromab, PF06946860, PF-06946860, PF 06946860
Target
TGF-beta/Smad
Conjugation
Unconjugated
Field of Research
Stem Cell & Developmental Biology
Concentration
7.69 mg/mL
Purity
>95% (May vary between batches)
Molecular Weight
146.08 kDa
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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