Elezanumab Antibody
Elezanumab (ABT-555) is a high-affinity human monoclonal antibody targeting RGMa, potently inhibiting RGMa-mediated BMP/SMAD1/5/8 signaling. It has demonstrated neuroprotective and axonal regenerative effects in preclinical models of spinal cord injury and demyelination, promoting corticospinal tract sprouting and serotonergic innervation.
Product Specifications
Product Name Alternative
Elezanumab, ABT 555, ABT555, ABT-555, AE12-1Y-QL, TGFβ, TGF-β/Smad, TGFb, TGF-b/Smad, TGFbeta, TGF-beta, TGFbeta/Smad, TGF-beta/Smad, Smad
Target
RGM, TGF-beta/Smad
Clonality
Monoclonal
Conjugation
Unconjugated
Field of Research
Neuroscience, Stem Cell & Developmental Biology
Concentration
4.65 mg/mL
Purity
97.20% (May vary between batches)
Molecular Weight
143.43 kDa
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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