EGFR-IN-131
EGFR-IN-131 (compound 3a) is a potent and cross the blood-brain barrier EGFR inhibitor with an IC50 value of 272.9 nM. EGFR-IN-131 shows antiproliferative activity. EGFR-IN-131 induces apoptosis and cell cycle arrest at G0/G1 phase. EGFR-IN-131 decreases the protein expression of p-EGFR[1].
Product Specifications
UNSPSC
12352101
Target
Apoptosis; EGFR
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-131.html
Smiles
CC(C1=CC(NC2=CC3=CC=N2)=CC=C1)OCCCC(NC4=NC(C5=CC=C(C=C5)F)=C3S4)=O
Molecular Formula
C26H23FN4O2S
Molecular Weight
474.55
References & Citations
[1]Wu G, et al. Discovery of novel Macrocyclic small molecules Based on 2-Amino-4-thiazolylpyridineas selective EGFR inhibitors with high Blood-Brain barrier penetration for the treatment of glioblastoma. Bioorg Chem. 2024 Oct 23;153:107905.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1
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