Spongionellol A
Product Specifications
UNSPSC Description
Spongionellol A is a MDR1 (p-glycoprotein) inhibitor. Spongionellol A has high cytotoxic activity and selectivity in prostate cancer cells by inducing caspase‑dependent apoptosis. Spongionellol A can be used in the research of cancers, such as prostate cancer[1].
Target Antigen
P-glycoprotein
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/spongionellol-a.html
Solubility
10 mM in DMSO
Smiles
CC(O[C@H]1[C@]23[C@@](CC[C@H]([C@@]2([H])C(O[C@H]3OC(C)=O)OC(C)=O)C(OC)=O)([H])[C@@]4([C@@](C(C)(CCC4)C)([H])C1)C)=O
Molecular Weight
508.60
References & Citations
[1]Sergey A Dyshlovoy, et al. New diterpenes from the marine sponge Spongionella sp. overcome drug resistance in prostate cancer by inhibition of P-glycoprotein. Sci Rep. 2022 Aug 9;12(1):13570.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N10491/Spongionellol-A-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N10491/
Clinical Information
No Development Reported
Curated Selection
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