Spongionellol A

Spongionellol A is a MDR1 (p-glycoprotein) inhibitor. Spongionellol A has high cytotoxic activity and selectivity in prostate cancer cells by inducing caspase‑dependent apoptosis. Spongionellol A can be used in the research of cancers, such as prostate cancer[1].

Product Specifications

UNSPSC

12352005

Target

P-glycoprotein

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/spongionellol-a.html

Solubility

10 mM in DMSO

Smiles

CC(O[C@H]1[C@]23[C@@](CC[C@H]([C@@]2([H])C(O[C@H]3OC(C)=O)OC(C)=O)C(OC)=O)([H])[C@@]4([C@@](C(C)(CCC4)C)([H])C1)C)=O

Molecular Formula

C27H40O9

Molecular Weight

508.60

References & Citations

[1]Sergey A Dyshlovoy, et al. New diterpenes from the marine sponge Spongionella sp. overcome drug resistance in prostate cancer by inhibition of P-glycoprotein. Sci Rep. 2022 Aug 9;12 (1) :13570.