D-Cysteine

D-Cysteine, the D-isomer of cysteine, is an orally active antibacterial agent and a regulator of neural progenitor cell proliferation. D-Cysteine can inhibit Escherichia coli, Streptococcus mutans, and Streptococcus sanguinis. The no-observed-adverse-effect level of D-Cysteine in rats should be less than 500 mg/kg/day[1][2][3][4].

Product Specifications

CAS Number

[921-01-7]

UNSPSC

12352211

Hazard Statement

H302

Target

Bacterial; Endogenous Metabolite

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/d-cysteine.html

Purity

98.0

Solubility

H2O : 4 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

N[C@H](CS)C(O)=O

Molecular Formula

C3H7NO2S

Molecular Weight

121.16

Precautions

H302

References & Citations

[1]Soutourina J, et al. Role of D-cysteine desulfhydrase in the adaptation of Escherichia coli to D-cysteine. J Biol Chem. 2001 Nov 2;276 (44) :40864-72.|[2]Guo X1, et al. Effect of D-cysteine on dual-species biofilms of Streptococcus mutans and Streptococcus sanguinis. Sci Rep. 2019 Apr 30;9 (1) :6689.|[3]Shibui Y, et al. Comparisons of l-cysteine and d-cysteine toxicity in 4-week repeated-dose toxicity studies of rats receiving daily oral administration. J Toxicol Pathol. 2017 Jul;30 (3) :217-229.|[4]Roychaudhuri R, et al. Mammalian D-cysteine: A novel regulator of neural progenitor cell proliferation Mammalian D-cysteine: A novel regulator of neural progenitor cell proliferation Endogenous D-cysteine, the stereoisomer with rapid spontaneous in vitro racemization rate, has major neural roles. Bioessays. 2022 Jul;44 (7) :e2200002.