Teprotumumab Antibody
Teprotumumab is a human monoclonal antibody targeting the IGF-1 receptor's extracellular domain. It inhibits TSH and IGF-1 signaling in fibrocytes, reducing pro-inflammatory cytokine expression and Akt phosphorylation, making it a key research tool for studying thyroid-associated ophthalmopathy in both cellular and animal models.
Product Specifications
Product Name Alternative
Teprotumumab, TSH Receptor, TSHReceptor, R1507, R-1507, R 1507, HZN 001, HZN001, HZN-001, IGF-1R, IGF1R
Target
IGF-1R, TSH Receptor
Clonality
Monoclonal
Conjugation
Unconjugated
Field of Research
Pharmacology & Drug Discovery, Signal Transduction
Concentration
2.74 mg/mL
Purity
95.20% (May vary between batches)
Molecular Weight
145.62 kDa
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Available Sizes
Frequently Asked Questions
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