5-FAM-GPHRSTPESRAAV (Presenilin 1 Domain)

<strong>5-FAM-GPHRSTPESRAAV (Presenilin 1 Domain)</strong>_x000D_ <strong>Catalog number:</strong> B2019437_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 1 mg_x000D_ <strong>Molecular Weight or Concentration:</strong> 1722.8_x000D_ <strong>Supplied as:</strong> Powder_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20°C_x000D_ <strong>Keywords:</strong> GPHRSTPESRAAV, 5 - FAM labeled_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Venegas C, Kumar S, Franklin BS, Dierkes T, Brinkschulte R, Tejera D, Vieira-Saecker A, Schwartz S, Santarelli F, Kummer MP, Griep A, Gelpi E, Beilharz M, Riedel D, Golenbock DT, Geyer M, Walter J, Latz E, Heneka MT. Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease Nature. 2017 Dec 20;552(7685):355-361._x000D_ 2: Hur JY, Frost GR, Wu X, Crump C, Pan SJ, Wong E, Barros M, Li T, Nie P, Zhai Y, Wang JC, Tcw J, Guo L, McKenzie A, Ming C, Zhou X, Wang M, Sagi Y, Renton AE, Esposito BT, Kim Y, Sadleir KR, Trinh I, Rissman RA, Vassar R, Zhang B, Johnson DS, Masliah E, Greengard P, Goate A, Li YM. The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease Nature. 2020 Oct;586(7831):735-740._x000D_ 3: Sun J, Zhang Y, Kong Y, Ye T, Yu Q, Kumaran Satyanarayanan S, Su KP, Liu J. Microbiota-derived metabolite Indoles induced aryl hydrocarbon receptor activation and inhibited neuroinflammation in APP/PS1 mice Brain Behav Immun. 2022 Nov;106:76-88._x000D_ 4: Tandon A, Fraser P. The presenilins Genome Biol. 2002 Oct 23;3(11):reviews3014._x000D_ 5: Li Y, Bohm C, Dodd R, Chen F, Qamar S, Schmitt-Ulms G, Fraser PE, St George-Hyslop PH. Structural biology of presenilin 1 complexes Mol Neurodegener. 2014 Dec 18;9:59._x000D_ 6: Unger MS, Li E, Scharnagl L, Poupardin R, Altendorfer B, Mrowetz H, Hutter-Paier B, Weiger TM, Heneka MT, Attems J, Aigner L. CD8(+) T-cells infiltrate Alzheimer's disease brains and regulate neuronal- and synapse-related gene expression in APP-PS1 transgenic mice Brain Behav Immun. 2020 Oct;89:67-86._x000D_ 7: Montenegro P, Chen P, Kang J, Lee SH, Leone S, Shen J. Human Presenilin-1 delivered by AAV9 rescues impaired γ-secretase activity, memory deficits, and neurodegeneration in Psen mutant mice Proc Natl Acad Sci U S A. 2023 Oct 17;120(42):e2306714120._x000D_ 8: Johnson DS, Li YM, Pettersson M, St George-Hyslop PH. Structural and Chemical Biology of Presenilin Complexes Cold Spring Harb Perspect Med. 2017 Dec 1;7(12):a024067._x000D_ 9: Maesako M, Horlacher J, Zoltowska KM, Kastanenka KV, Kara E, Svirsky S, Keller LJ, Li X, Hyman BT, Bacskai BJ, Berezovska O. Pathogenic PS1 phosphorylation at Ser367 Elife. 2017 Jan 30;6:e19720._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/24099007">10: Wolfe MS. Toward the structure of presenilin/γ-secretase and presenilin homologs Biochim Biophys Acta. 2013 Dec;1828(12):2886-97. </a>_x000D_ _x000D_ <strong>Products Related to 5-FAM-GPHRSTPESRAAV (Presenilin 1 Domain) can be found at</strong> <a href="https://moleculardepot.com/product-category/Peptides/"> Peptides</a>