Sodium propionate

Sodium propionate is an orally active short-chain fatty acid. Sodium propionate can be produced by intestinal bacteria from the metabolism of dietary fiber. Sodium propionate increases PPAR-γ, inhibits NF-κB activation, and reduces COX-2 expression and NO production. Sodium propionate also induces Apoptosis and Autophagy. Sodium propionate reduces HSV-1-induced keratitis. Sodium propionate has anticancer effects against glioblastoma. Sodium propionate exhibits neuroprotective, antioxidant, and anti-inflammatory activities. Sodium propionate can be used in the research of spinal cord injury and Alzheimer's disease[1][2][3][4][5][6].

Product Specifications

CAS Number

[137-40-6]

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Autophagy; Bacterial; COX; Endogenous Metabolite; HSV; NF-κB; NO Synthase; PPAR

Type

Biochemical Assay Reagents

Related Pathways

Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor

Field of Research

Cancer; Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sodium-propionate.html

Purity

99.0

Solubility

DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : ≥ 200 mg/mL

Smiles

O=C(CC)O[Na]

Molecular Formula

C3H5NaO2

Molecular Weight

96.06

Precautions

H302, H315, H319, H335

References & Citations

[1]Filippone A, et al. Sodium Propionate Contributes to Tumor Cell Growth Inhibition through PPAR-γ Signaling. Cancers (Basel) . 2022 Dec 29;15 (1) :217. |[2]Filippone A, et al. The anti-inflammatory and antioxidant effects of sodium propionate. International journal of molecular sciences, 2020, 21 (8) : 3026.|[3]Filippone A, et al. Protective effect of sodium propionate in Aβ1-42-induced neurotoxicity and spinal cord trauma. Neuropharmacology. 2020 Apr;166:107977.|[4]Park HS, et al. Sodium propionate exerts anticancer effect in mice bearing breast cancer cell xenograft by regulating JAK2/STAT3/ROS/p38 MAPK signaling. Acta Pharmacol Sin. 2021 Aug;42 (8) :1311-1323. |[5]Sumbria D, et al. Supplementing the Diet with Sodium Propionate Suppresses the Severity of Viral Immuno-inflammatory Lesions. J Virol. 2021 Jan 28;95 (4) :e02056-20. |[6]Lang W, et al. Sodium propionate improves cognitive and memory function in mouse models of Alzheimer's disease. Neurosci Lett. 2022 Nov 20;791:136887.