BMPR2-IN-1
BMPR2-IN-1 (Compound 8a) is a BMPR2 inhibitor with an IC50 of 506 nM and a KD of 83.5 nM. BMPR2-IN-1 can be used for research of pulmonary arterial hypertension, Alzheimer’s disease and cancer[1].
Product Specifications
UNSPSC
12352005
Target
TGF-β Receptor
Type
Reference compound
Related Pathways
TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bmpr2-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C1NCCC2=CC=C(NC3=NC(NC4=NNC1=C4)=CC=N3)C=C2
Molecular Formula
C16H15N7O
Molecular Weight
321.34
References & Citations
[1]Amrhein JA, et al. Design and Synthesis of Pyrazole-Based Macrocyclic Kinase Inhibitors Targeting BMPR2. ACS Med Chem Lett. 2023 May 30;14 (6) :833-840.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS9920005-01 48 Well
Monkey Ethanolamine-Phosphate Cytidylyltransferase (PCYT2) ELISA Kit
Sign In for Pricing
View Details MBS9920005-02 96 Well
Monkey Ethanolamine-Phosphate Cytidylyltransferase (PCYT2) ELISA Kit
Sign In for Pricing
View Details MBS9920005-03 5x 96 Well
Monkey Ethanolamine-Phosphate Cytidylyltransferase (PCYT2) ELISA Kit
Sign In for Pricing
View Details MBS9920005-04 10x 96 Well
Monkey Ethanolamine-Phosphate Cytidylyltransferase (PCYT2) ELISA Kit
Sign In for Pricing
View Details 
SC213867 10 µg
Myelin oligodendrocyte glycoprotein (MOG) (NM_206813) Human 3' UTR Clone
Sign In for Pricing
View Details