Ornidazole (Levo-)

Levo-ornidazole ((S) -Ornidazole) is the L-isomer of Ornidazole. Ornidazole (Levo-) increases GAD 65/67 expression and decreases brain Glu/GABA ratio. Ornidazole (Levo-) has a mild sedative effect. Levo-ornidazole can be used in the research of anti-anaerobic and anti-parasitic agents[1][2].

Product Specifications

CAS Number

[166734-83-4]

Product Name Alternative

(S) -Ornidazole; Levornidazole

UNSPSC

12352005

Hazard Statement

H301-H311-H331-H341

Target

Bacterial; Drug Isomer; GABA Receptor; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Applications

COVID-19-immunoregulation

Field of Research

Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Ornidazole-Levo-.html

Purity

98.86

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 6.67 mg/mL (ultrasonic)

Smiles

CC1=NC=C([N+]([O-])=O)N1C[C@H](O)CCl

Molecular Formula

C7H10ClN3O3

Molecular Weight

219.63

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P403+P233-P405-P501

References & Citations

[1]Guo B, et al. Clinical Pharmacokinetics of Levornidazole in Elderly Subjects and Dosing Regimen Evaluation Using Pharmacokinetic/Pharmacodynamic Analysis. Clin Ther. 2017 Jul;39 (7) :1336-1346.|[2]Wei TT, et al. Effects of the ornidazole enantiomers on the central nervous system: Involvement of the GABAA receptor. Chem Biol Interact. 2015 Dec 5;242:163-9.