Triapine

Triapine (3-AP; PAN-811) is a potent inhibitor of the M2 subunit of ribonucleotide reductase (RR), and is a potent radiosensitizer.

Product Specifications

CAS Number

[143621-35-6]

Product Name Alternative

3-AP; PAN-811; OCX191

UNSPSC

12352005

Hazard Statement

H301, H315, H319, H335

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/triapine.html

Purity

99.78

Solubility

DMSO : ≥ 47 mg/mL

Smiles

S=C(N)N/N=C/C1=NC=CC=C1N

Molecular Formula

C7H9N5S

Molecular Weight

195.24

Precautions

H301, H315, H319, H335

References & Citations

[1]Martin LK, et al. A dose escalation and pharmacodynamic study of Triapine and radiation in patients with locally advanced pancreas cancer. Int J Radiat Oncol Biol Phys. 2012 Nov 15;84 (4) :e475-81.|[2]Yalowich JC, et al. The anticancer thiosemicarbazones Dp44mT and Triapine lack inhibitory effects as catalytic inhibitors or poisons of DNA topoisomerase IIα. Biochem Pharmacol. 2012 Jul 1;84 (1) :52-8.|[3]Whitnall M, et al. A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics. Proc Natl Acad Sci U S A. 2006 Oct 3;103 (40) :14901-6.