Triapine
Triapine (3-AP; PAN-811) is a potent inhibitor of the M2 subunit of ribonucleotide reductase (RR), and is a potent radiosensitizer.
Product Specifications
CAS Number
143621-35-6
Product Name Alternative
3-AP; PAN-811; OCX191
UNSPSC
12352005
Hazard Statement
H301, H315, H319, H335
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/triapine.html
Purity
99.78
Solubility
DMSO : ≥ 47 mg/mL
Smiles
S=C(N)N/N=C/C1=NC=CC=C1N
Molecular Formula
C7H9N5S
Molecular Weight
195.24
Precautions
H301, H315, H319, H335
References & Citations
[1]Martin LK, et al. A dose escalation and pharmacodynamic study of Triapine and radiation in patients with locally advanced pancreas cancer. Int J Radiat Oncol Biol Phys. 2012 Nov 15;84 (4) :e475-81.|[2]Yalowich JC, et al. The anticancer thiosemicarbazones Dp44mT and Triapine lack inhibitory effects as catalytic inhibitors or poisons of DNA topoisomerase IIα. Biochem Pharmacol. 2012 Jul 1;84 (1) :52-8.|[3]Whitnall M, et al. A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics. Proc Natl Acad Sci U S A. 2006 Oct 3;103 (40) :14901-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
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