Phentolamine

Phentolamine is a potent, selective and orally active α1 adrenergic and α2 adrenergic receptor antagonist. Phentolamine can be used for the research of erectile dysfunction[1][2][3].

Product Specifications

CAS Number

[50-60-2]

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology; Cancer

Assay Protocol

https://www.medchemexpress.com/phentolamine.html

Concentration

10mM

Purity

99.94

Solubility

DMSO : 116.67 mg/mL (ultrasonic)

Smiles

OC1=CC=CC(N(CC2=NCCN2)C3=CC=C(C)C=C3)=C1

Molecular Formula

C17H19N3O

Molecular Weight

281.35

Precautions

H302, H312, H332

References & Citations

[1]Goldstein I I. Oral phentolamine: an alpha-1, alpha-2 adrenergic antagonist for the treatment of erectile dysfunction. Int J Impot Res. 2000 Mar;12 (S1) :S75-S80 |[2]Amabeoku G, et al. Strychnine-induced seizures in mice: the role of noradrenaline. Prog Neuropsychopharmacol Biol Psychiatry. 1994 Jul;18 (4) :753-63.|[3]Fagerholm V, et al. alpha2A-adrenoceptor antagonism increases insulin secretion and synergistically augments the insulinotropic effect of glibenclamide in mice. Br J Pharmacol. 2008 Jul;154 (6) :1287-96.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

α adrenergic receptor

Citation 01

J Cancer. 2024 Sep 9;15 (17) :5691-5709.|Neurosci Bull. 2023 Dec;39 (12) :1789-1806.|bioRxiv. 2023 Oct 13.|J Endocrinol. 2020 Mar;244 (3) :459-471.|Insect Biochem Mol Biol. 2025 May:180:104312.