ABCA1 inducer 1
ABCA1 inducer 1 is a nonlipogenic ABCA1 inducer. ABCA1 inducer 1 increases ABCA1 expression, enhances apolipoprotein (APOE) lipidation and reverses multiple Alzheimer’s disease (AD) phenotypes, without increasing triglycerides in E3/4FAD mice that express human APOE 3/4[1].
Product Specifications
CAS Number
2839627-76-6
UNSPSC
12352005
Target
Apolipoprotein
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/abca1-inducer-1.html
Smiles
CCOC(C1=CC(NC(C2=C(C=C(S2)Cl)S(=O)(N(C3=CC(OC)=C(C=C3)OCC)C)=O)=O)=CC(Cl)=C1)=O
Molecular Formula
C24H24Cl2N2O7S2
Molecular Weight
587.49
References & Citations
[1]Velma GR, et al. Nonlipogenic ABCA1 Inducers (NLAI) for Alzheimer's Disease Validated in a Mouse Model Expressing Human APOE3/APOE4. J Med Chem. 2024 Sep 12;67 (17) :15061-15079.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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