NJH-2-056
NJH-2-056 is a deubiquitinase-targeting chimera (DUBTAC) linking the OTUB1 recruiter EN523 to the CFTR chaperone lumacaftor. NJH-2-056 can be used for cystic fibrosis research[1].
Product Specifications
CAS Number
[2858812-69-6]
UNSPSC
12352005
Target
CFTR; PROTACs
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/njh-2-056.html
Purity
98.23
Solubility
DMSO : ≥ 100 mg/mL
Smiles
C=CC(N1CCN(C(C1)=O)C2=CC=C(O2)CCC(NCCCNC(C3=CC=CC(C4=NC(NC(C5(CC5)C6=CC=C7OC(F)(OC7=C6)F)=O)=CC=C4C)=C3)=O)=O)=O
Molecular Formula
C41H40F2N6O8
Molecular Weight
782.79
References & Citations
[1]Henning NJ, et al. Deubiquitinase-targeting chimeras for targeted protein stabilization. Nat Chem Biol. 2022 Apr;18 (4) :412-421.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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