NJH-2-056
Product Specifications
UNSPSC Description
NJH-2-056 is a deubiquitinase-targeting chimera (DUBTAC) linking the OTUB1 recruiter EN523 to the CFTR chaperone lumacaftor. NJH-2-056 can be used for cystic fibrosis research[1].
Target Antigen
CFTR; PROTACs
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/njh-2-056.html
Solubility
DMSO : ≥ 100 mg/mL
Smiles
C=CC(N1CCN(C(C1)=O)C2=CC=C(O2)CCC(NCCCNC(C3=CC=CC(C4=NC(NC(C5(CC5)C6=CC=C7OC(F)(OC7=C6)F)=O)=CC=C4C)=C3)=O)=O)=O
Molecular Weight
782.79
References & Citations
[1]Henning NJ, et al. Deubiquitinase-targeting chimeras for targeted protein stabilization. Nat Chem Biol. 2022 Apr;18(4):412-421.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-143344/NJH-2-056-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-143344/NJH-2-056-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2858812-69-6
Available Sizes
Curated Selection
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