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CBu-Cit-OH

CBu-Cit-OH (Mal-cyclobutane-1) is an ADC Linker that can be used to synthesize ADCs[1].

Product Specifications

CAS Number

1799663-03-8

Product Name Alternative

Mal-cyclobutane-1,1-dicarboxamide-Cit-PAB

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

ADC Linker

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cbu-cit-oh.html

Solubility

10 mM in DMSO

Smiles

OCC1=CC=C(NC([C@H](CCCNC(N)=O)NC(C2(C(NCCCCCN3C(C=CC3=O)=O)=O)CCC2)=O)=O)C=C1

Molecular Formula

C28H38N6O7

Molecular Weight

570.64

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Wei B, et al. Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity. J Med Chem. 2018 Feb 8;61 (3) :989-1000.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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