MK2-IN-3 (hydrate)

MK2-IN-3 hydrate (compound 16) is an orally active, selective, and ATP-competitive MAPKAP-K2 (MK-2) inhibitor with an IC50 of 0.85 nM.MK2-IN-3 hydrate is exceptional selectivity against MK-3 (IC50=0.21 μM), MK-5 (IC50=0.081 μM), ERK2 (IC50=3.44 μM), MNK1 (IC50=5.7 μM) as well as CDK2, JNK2, IKK2, MSK1, and MSK2[1].

Product Specifications

CAS Number

[1186648-22-5]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

MAPKAPK2 (MK2)

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/mk-2-inhibitor-iii.html

Purity

99.0

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1C2=C(NC(C3=CC(C4=CC5=CC=CC=C5N=C4)=NC=C3)=C2)CCN1.O

Molecular Formula

C21H18N4O2

Molecular Weight

358.39

Precautions

H315, H319

References & Citations

[1]Anderson DR, et al. Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2) . J Med Chem. 2007 May 31;50 (11) :2647-54.