CBS-3595
CBS-3595 is a dual inhibitor of p38 MAP kinase and phosphodiesterase 4 with anti-inflammatory and anti-allodynic activities. CBS-3595 reduces the production of the proinflammatory cytokine IL-6 and increases the levels of the anti-inflammatory cytokine IL-10 in rats. CBS-3595 reduces paw oedema formation in the Complete Freund’s adjuvant (CFA) -induced arthritis rat model. CBS-3595 is promising for research of autoimmune diseases[1].
Product Specifications
CAS Number
908380-97-2
UNSPSC
12352005
Target
P38 MAPK; Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cbs-3595.html
Smiles
CC(NC1=NC=CC(C2=C(C3=CC=C(F)C=C3)N=C(S(C)=O)N2C)=C1)=O
Molecular Formula
C18H17FN4O2S
Molecular Weight
372.42
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Frequently Asked Questions
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