Gliotoxin
Gliotoxin is a secondary metabolite, the most abundant mycotoxin secreted by A. fumigatus, inhibits the phagocytosis of macrophages and the immune functions of other immune cells [1]. Gliotoxin inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces host-cell apoptosis[2]. Gliotoxin activates PKA and increases intracellular cAMP concentration; modulates actin cytoskeleton rearrangement to facilitate A. fumigatus internalization into lung epithelial cells[3]. Gliotoxin is a potent NOTCH2 transactivation inhibitor, can effectively induce apoptosis of chronic lymphocytic leukemia (CLL) cells[4].
Product Specifications
CAS Number
67-99-2
Product Name Alternative
Aspergillin
UNSPSC
12352005
Hazard Statement
H301
Target
Antibiotic; Apoptosis; Bacterial; Fungal; NF-κB; PKA
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; NF-κB; Stem Cell/Wnt; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gliotoxin.html
Purity
99.51
Solubility
DMF : 5 mg/mL (ultrasonic; warming) |DMSO : 5 mg/mL (ultrasonic; warming)
Smiles
O=C1N([C@]2(C(N3[C@]1(CC4=CC=C[C@@H]([C@@]34[H])O)SS2)=O)CO)C
Molecular Formula
C13H14N2O4S2
Molecular Weight
326.39
Precautions
H301
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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