(E)-MS0019266
Product Specifications
UNSPSC Description
(E)-MS0019266 is a potent inhibitor of DNA damage repair. (E)-MS0019266 inhibits ribonucleotide reductase by generating reactive oxygen species. (E)-MS0019266 also reduces expression of genes related to cell cycle arrest and mitosis, including polo-like kinase 1, kinesin family member 20a, cyclin B1 and aurora kinase A. (E)-MS0019266 is promising for research of inhibitors of ribonucleotide reductase and polo-like kinase 1[1].
Target Antigen
Others
Type
Reference compound
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/e-ms0019266.html
Smiles
C1(/C=N/NC2=NC=CC=C2)=NC=CC=C1
Molecular Weight
198.22
References & Citations
[1]Fu S, et al. γ-H2AX kinetics as a novel approach to high content screening for small molecule radiosensitizers. PLoS One. 2012;7(6):e38465.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-129727/E-MS0019266-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-129727/
Clinical Information
No Development Reported
CAS Number
21945-37-9
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