(E) -MS0019266
(E) -MS0019266 is a potent inhibitor of DNA damage repair. (E) -MS0019266 inhibits ribonucleotide reductase by generating reactive oxygen species. (E) -MS0019266 also reduces expression of genes related to cell cycle arrest and mitosis, including polo-like kinase 1, kinesin family member 20a, cyclin B1 and aurora kinase A. (E) -MS0019266 is promising for research of inhibitors of ribonucleotide reductase and polo-like kinase 1[1].
Product Specifications
CAS Number
[21945-37-9]
UNSPSC
12352005
Target
DNA/RNA Synthesis; Mitosis; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/e-ms0019266.html
Smiles
C1(/C=N/NC2=NC=CC=C2)=NC=CC=C1
Molecular Formula
C11H10N4
Molecular Weight
198.22
References & Citations
[1]Fu S, et al. γ-H2AX kinetics as a novel approach to high content screening for small molecule radiosensitizers. PLoS One. 2012;7 (6) :e38465.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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