Anti-Beta-Defensin-3 Antibody

Rabbit Polyclonal Antibody specific to beta-Defensin-3

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

Beta-defensin 3, BD-3, DEFB-3, HBD3, hBD-3, Defensin, beta 103, Defensin-like protein

Gene Name

DEFB103A

NCBI Gene ID

UniProt

P81534

Accession Number

NP_001075020.1

Cellular Locus

Secreted.

Host

Rabbit

Reactivity

Human

Immunogen

Full-length human beta- defensin 3.

Target Antigen

Beta-defensin 103

Target

Beta-Defensin-3

Clonality

Polyclonal

Type

Antibody

Applications

Field of Research

Infectious Disease

Purification Method

Purified by immunoaffinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed. {PubMed:11085990}.

Additionnal Information

Immunoblotting: use at 1:500-1:1,000 dilution. In immunoblots, a band of approximately 5 kD is detected.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C to -70°C. Store antibody in appropriate aliquots to avoid multiple freeze-thaw cycles.

Specificity

This antibody specifically recognizes human beta-defensin-3, a nonhemolytic antimicrobial peptide originally isolated from human lesional psoriatic scales and cloned from human keratinocytes. Beta-defensin-3 appears to play a role in natural epithelial defense against infections by a broad spectrum of pathogenic microorganisms.