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κM-Conotoxin RIIIJ

Product Specifications

UNSPSC Description

κM-Conotoxin RIIIJ (κM-RIIIJ) is a selective Kv1.2 inhibitor with an IC50 of 33 nM[1].

Target Antigen

Potassium Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Solubility

10 mM in DMSO

Smiles

O=C([C@@H](N)CC(C)C)N1C[C@@H](C[C@H]1C(N2C[C@@H](C[C@H]2C(N[C@H](C(N[C@H](C(N[C@H](C(N3C[C@@H](C[C@H]3C(N4C[C@@H](C[C@H]4C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N5C[C@@H](C[C@H]5C(N[C@H](C(N6C[C@@H](C[C@H]6C(N[C@H]7C)=O)O)=O)C)=O)O)=O)CSSC[C@@H](C(N[C@H](C(N[C@H](C(O)=O)CO)=O)CCCCN)=O)NC8=O)=O)CC9=CNC=N9)=O)CCCCN)=O)CCCCN)=O)O)=O)O)=O)[C@@H](C)O)=O)CSSC[C@@H]8NC%10=O)=O)CSSC[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N%11C[C@@H](C[C@H]%11%10)O)=O)CCCCN)=O)CC%12=CC=C(O)C=C%12)=O)CCCCN)=O)NC7=O)=O)O)=O)O

Molecular Weight

2807.30

References & Citations

[1]Chen P, et al. Biochemical characterization of kappaM-RIIIJ, a Kv1.2 channel blocker: evaluation of cardioprotective effects of kappaM-conotoxins. J Biol Chem. 2010 May 14;285(20):14882-14889.

Shipping Conditions

Room temperature

Clinical Information

No Development Reported

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