κM-Conotoxin RIIIJ
Product Specifications
UNSPSC Description
κM-Conotoxin RIIIJ (κM-RIIIJ) is a selective Kv1.2 inhibitor with an IC50 of 33 nM[1].
Target Antigen
Potassium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](N)CC(C)C)N1C[C@@H](C[C@H]1C(N2C[C@@H](C[C@H]2C(N[C@H](C(N[C@H](C(N[C@H](C(N3C[C@@H](C[C@H]3C(N4C[C@@H](C[C@H]4C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N5C[C@@H](C[C@H]5C(N[C@H](C(N6C[C@@H](C[C@H]6C(N[C@H]7C)=O)O)=O)C)=O)O)=O)CSSC[C@@H](C(N[C@H](C(N[C@H](C(O)=O)CO)=O)CCCCN)=O)NC8=O)=O)CC9=CNC=N9)=O)CCCCN)=O)CCCCN)=O)O)=O)O)=O)[C@@H](C)O)=O)CSSC[C@@H]8NC%10=O)=O)CSSC[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N%11C[C@@H](C[C@H]%11%10)O)=O)CCCCN)=O)CC%12=CC=C(O)C=C%12)=O)CCCCN)=O)NC7=O)=O)O)=O)O
Molecular Weight
2807.30
References & Citations
[1]Chen P, et al. Biochemical characterization of kappaM-RIIIJ, a Kv1.2 channel blocker: evaluation of cardioprotective effects of kappaM-conotoxins. J Biol Chem. 2010 May 14;285(20):14882-14889.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
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