DNA-PKcs Rabbit mAb [KD Validated] Antibody
DNA-dependent protein kinase (DNA-PK) is an important factor in the repair of double-stranded breaks in DNA. Cells lacking DNA-PK or in which DNA-PK is inhibited fail to show proper nonhomologous end-joining (NHEJ) . DNA-PK is composed of two DNA-binding subunits (Ku70 and Ku86) and one 450 kDa catalytic subunit (DNA-PKcs) . It is thought that a heterodimer of Ku70 and Ku86 binds to double-stranded DNA broken ends before DNA-PKcs binds and is activated.
Product Specifications
Product Name Alternative
DNA-PKcs; DNA-dependent protein kinase catalytic subunit; DNPK1; EC 2.7.11.1; P460; PRKD; PRKDC; XRCC7, kinase DNA PK; DNA PKcs
UniProt
P78527
Reactivity
Human, Mouse, Rat
Immunogen
A synthesized peptide derived from human DNA-PKcs
Clonality
Monoclonal
Conjugation
Unconjugated
Field of Research
Epigenetics & Chromatin
Purification
Affinity-chromatography
Dilution
WB 1:1000~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200
Form
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
ICC, IHC, WB
Host or Source
Rabbit
Isotype
Rabbit IgG
Available Sizes
Frequently Asked Questions
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