NPC-567
Product Specifications
UNSPSC Description
NPC-567 is a bradykinin B2 receptor antagonist. NPC-567 is effective in inhibiting the acute response to allergen in the airways[1][2].
Target Antigen
Bradykinin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/npc-567.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@H](CC1=CC=CC=C1)C(N[C@H](C(N[C@H](C(O)=O)CCCNC(N)=N)=O)CC2=CC=CC=C2)=O)[C@H](CO)NC([C@@H](NC(CNC([C@H]3N(C([C@H]4N(C([C@@H](NC([C@H](N)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCC4)=O)C[C@H](O)C3)=O)=O)CC5=CC=CC=C5)=O
Molecular Weight
1282.45
References & Citations
[1]Cheronis JC, et al. A new class of bradykinin antagonists: synthesis and in vitro activity of bissuccinimidoalkane peptide dimers. J Med Chem. 1992 May 1;35(9):1563-72.|[2]Sylvin H, et al. The effect of a bradykinin B2 receptor antagonist, NPC-567, on allergen-induced airway responses in a porcine model. Inflamm Res. 2001 Sep;50(9):453-9.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P2118/NPC-567-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P2118/
Clinical Information
Phase 2
CAS Number
109333-26-8
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