4'-Hydroxy flurbiprofen

4'-Hydroxy flurbiprofen is an oxidative metabolite of Flurbiprofen (HY-10582) via the cytochrome P450 enzyme system. 4'-Hydroxy flurbiprofen inhibits COX-1 by 94% at a concentration of 1000 µM[1].

Product Specifications

CAS Number

[52807-12-2]

UNSPSC

12352005

Hazard Statement

H301

Target

COX; Drug Metabolite

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/4-hydroxy-flurbiprofen.html

Purity

99.28

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C1=CC=C(C2=CC=C(C=C2)O)C(F)=C1)C(O)=O

Molecular Formula

C15H13FO3

Molecular Weight

260.26

Precautions

H301

References & Citations

[1]Karlsson J, Fowler CJ. Inhibition of endocannabinoid metabolism by the metabolites of ibuprofen and flurbiprofen. PLoS One. 2014 Jul 25;9 (7) :e103589.|[2]Tracy TS, et al. Studies of flurbiprofen 4'-hydroxylation. Additional evidence suggesting the sole involvement of cytochrome P450 2C9. Biochem Pharmacol. 1996 Oct 25;52 (8) :1305-9.