Ertiprotafib
Ertiprotafib is an inhibitor of PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist, with an IC50 of 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM for PPARα/PPARβ.
Product Specifications
CAS Number
251303-04-5
Product Name Alternative
PTP 112
UNSPSC
12352005
Target
IKK; Phosphatase; PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Ertiprotafib.html
Purity
98.13
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC([C@@H](CC1=CC=CC=C1)OC2=C(C)C=C(C3=C(C(C)=C(C)S4)C4=C(Br)C5=CC=CC=C53)C=C2C)=O
Molecular Formula
C31H27BrO3S
Molecular Weight
559.51
References & Citations
[1]Shrestha S, et al. PTP1B inhibitor Ertiprotafib is also a potent inhibitor of IkappaB kinase beta (IKK-beta) . Bioorg Med Chem Lett. 2007 May 15;17 (10) :2728-30. Epub 2007 Mar 3.|[2]Erbe DV, et al. Ertiprotafib improves glycemic control and lowers lipids via multiple mechanisms. Mol Pharmacol. 2005 Jan;67 (1) :69-77.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IKK-β; PPARα; PPARβ/δ
Available Sizes
Frequently Asked Questions
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