JMS-175-2
JMS-175-2 is a potent agonist of BRCC36 isopeptidase complex (BRISC), with the IC50 of 3.8 μM. JMS-175-2 plays an important role in Type I interferon-mediated diseases[1].
Product Specifications
CAS Number
[3042887-70-4]
UNSPSC
12352005
Target
Deubiquitinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/jms-175-2.html
Purity
98.13
Smiles
ClC1=CC=CC(Cl)=C1C(N2C=C(NC(C3=C(Cl)C=CC=C3Cl)=O)C(C(NC4CCNCC4)=O)=N2)=O
Molecular Formula
C23H19Cl4N5O3
Molecular Weight
555.24
References & Citations
[1]"Francesca Chandler, et al. Molecular glues that inhibit specific Zn2+-dependent DUB activity and inflammation. bioRxiv [Preprint]. 2024 Sep 7:2024.09.07.611787."
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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