NUMB Rabbit mAb [KD Validated] Antibody
Numb acts as a negative regulator of Notch signaling by promoting ubiquitination and degradation of Notch. The protein is asymmetrically segregated into one daughter cell during cell division, producing two daughter cells with different responses to Notch signaling and different cell fates. The localization of Numb can also be regulated by G-protein coupled receptor (GPCR) and PKC signaling.
Product Specifications
Product Name Alternative
C14_5527; h Numb; Numb; Numb homolog; S171
UniProt
P49757
Reactivity
Human, Mouse, Rat
Immunogen
A synthesized peptide derived from human NUMB
Clonality
Monoclonal
Conjugation
Unconjugated
Field of Research
Neuroscience
Purification
Affinity-chromatography
Dilution
WB 1:500~1:2000
Form
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Tested Applications
WB
Host or Source
Rabbit
Isotype
Rabbit IgG
Available Sizes
Frequently Asked Questions
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