Phenformin
Phenformin (1-phenethylbiguanide) is an orally active antidiabetic and anticancer agent. Phenformin has an incidence of associated lactic acidosis. Phenformin acts through acting AMPK activation and blocking mTOR pathway. Phenformin is also a substrate of P-glycoprotein (P-gp), and an OXPHOS inhibitor. Phenformin induces cancer cell apoptosis[1][2].
Product Specifications
CAS Number
114-86-3
Product Name Alternative
Phenethylbiguanide
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
AMPK; Apoptosis; Mitochondrial Metabolism
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics; Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/phenformin.html
Purity
99.72
Solubility
H2O : 350 mg/mL (ultrasonic)
Smiles
NC(NC(NCCC1=CC=CC=C1)=N)=N
Molecular Formula
C10H15N5
Molecular Weight
205.26
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
RT, protect from light
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Available Sizes
Frequently Asked Questions
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