Phenformin
Product Specifications
UNSPSC Description
Phenformin (1-phenethylbiguanide) is an orally active antidiabetic and anticancer agent. Phenformin has an incidence of associated lactic acidosis. Phenformin acts through acting AMPK activation and blocking mTOR pathway. Phenformin is also a substrate of P-glycoprotein (P-gp), and an OXPHOS inhibitor. Phenformin induces cancer cell apoptosis[1][2].
Target Antigen
AMPK; Apoptosis; Mitochondrial Metabolism
Type
Reference compound
Related Pathways
Apoptosis;Epigenetics;Metabolic Enzyme/Protease;PI3K/Akt/mTOR
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/phenformin.html
Solubility
H2O : 350 mg/mL (ultrasonic)
Smiles
NC(NC(NCCC1=CC=CC=C1)=N)=N
Molecular Weight
205.26
References & Citations
[1]García Rubiño ME, et al. Phenformin as an Anticancer Agent: Challenges and Prospects. Int J Mol Sci. 2019 Jul 5;20(13):3316.|[2]Yendapally R, et al. A review of phenformin, metformin, and imeglimin. Drug Dev Res. 2020 Jun;81(4):390-401.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-16397/Phenformin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-16397/Phenformin-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
114-86-3
Available Sizes
Curated Selection
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