Lithium chloride hydrate

Lithium chloride hydrate, an orally active mood stabilizer, is a potent virus inhibitor and effective immunomodulatory agent. Lithium chloride hydrate has antidepressant activity by inhibiting GSK3β and promoting neurogenesis. Lithium chloride hydrate alleviates cognition dysfunction and the symptoms of acute mania and depression. Lithium chloride hydrate can also be used for research of virus infection and Alzheimer's disease[1][2][3].

Product Specifications

CAS Number

[85144-11-2]

Product Name Alternative

Hydrate/monohydrateortrihydrate

UNSPSC

12352300

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; GSK-3

Type

Reference compound

Related Pathways

Apoptosis; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

COVID-19-anti-virus

Field of Research

Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/lithium-chloride-hydrate.html

Purity

99.56

Solubility

DMSO : 25 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL

Smiles

[Li]Cl.O

Molecular Formula

LiCl · xH2O

Molecular Weight

42.39 (anhydrous basis)

Precautions

H302, H315, H319, H335

References & Citations

[1]Liu X, et al. Lithium chloride inhibits infectious bronchitis virus-induced apoptosis and inflammation. Microb Pathog. 2022 Jan;162:105352. |[2]Wang, et al. Lithium chloride ameliorates cognition dysfunction induced by sevoflurane anesthesia in rats. FEBS Open Bio. 2020 Feb;10 (2) :251-258. |[3]Wang Z, et alL. Baicalin Coadministration with Lithium Chloride Enhanced Neurogenesis via GSK3β Pathway in Corticosterone Induced PC-12 Cells. Biol Pharm Bull. 2022 May 1;45 (5) :605-613. |[4]Tafreshi AP, Set al. Lithium chloride improves the efficiency of induced pluripotent stem cell-derived neurospheres. Biol Chem. 2015 Aug;396 (8) :923-8. |[5]Sahebgharani M, et al. Lithium chloride protects PC12 pheochromocytoma cell line from morphine-induced apoptosis. Arch Iran Med. 2008 Nov;11 (6) :639-48.