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DPQZ

DPQZ is an anti-tubulin agent that inhibits cell separation and induces cell cycle arrest at the G2/M phase. In addition, DPQZ induces caspase-dependent apoptosis of HSC-3 cells by inhibiting Ras/Raf and activating MAP kinase. DPQZ can be used in the study of oral cancer[1].

Product Specifications

CAS Number

1431362-93-4

UNSPSC

12352005

Target

Apoptosis; Caspase; Raf; Ras

Type

Reference compound

Related Pathways

Apoptosis; GPCR/G Protein; MAPK/ERK Pathway

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dpqz.html

Smiles

O=C1N=C(C2=C3C=CC=CC3=CC=C2)NC4=CC=C(N(C)C)C=C14

Molecular Formula

C20H17N3O

Molecular Weight

315.37

References & Citations

[1]Hour M J, et al. A novel antitubulin agent, DPQZ, induces cell apoptosis in human oral cancer cells through Ras/Raf inhibition and MAP kinases activation[J]. Archives of toxicology, 2013, 87: 835-846.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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