BR-cpd7
BR-cpd7 is a PROTAC degrader for fibroblast growth factor receptor FGFR1/2 with DC50 of 10 nM. BR-cpd7 arrests cell cycle, inhibits proliferations of FGFR1/2 aberrant activated tumor cells. (Pink: ligand for target protein FGFR-IN-12 ; Black: linker; Blue: ligand for E3 ligase Thalidomide-NH-CH2-COOH (HY-131717) )
Product Specifications
UNSPSC
12352005
Target
FGFR; PROTACs
Type
Reference compound
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/br-cpd7.html
Concentration
10mM
Purity
98.01
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=CC(OC)=C(C(NC(N(C2=CC(NC3=CC=C(C=C3)N4CCN(CC4)C5CCN(CC5)C(CNC6=CC=CC7=C6C(N(C7=O)C8CCC(NC8=O)=O)=O)=O)=NC=N2)C)=O)=C1Cl)Cl
Molecular Formula
C44H47Cl2N11O8
Molecular Weight
928.82
References & Citations
[1]Kong Y, et al., A Selective FGFR1/2 PROTAC Degrader with Antitumor Activity. Mol Cancer Ther. 2024 Jun 10:OF1-OF11.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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