Metallo-β-lactamase-IN-14

Metallo-β-lactamase-IN-14 (Compound 17e) is a Metallo-β-Lactamase inhibitor. Metallo-β-lactamase-IN-14 shows inhibition activity against VIM-1 and VIM-2. Metallo-β-lactamase-IN-14 has antibacterial activity against Gram-negative (GN) bacteria and P. aeruginosa[1].

Product Specifications

CAS Number

[1802367-43-6]

UNSPSC

12352005

Target

Beta-lactamase

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/metallo-β-lactamase-in-14.html

Solubility

10 mM in DMSO

Smiles

O=S(N)(C1=C(C2=NN=NN2)C(C3=C4N=C(N)SC4=CC=C3)=CC=C1CC5CCNCC5)=O

Molecular Formula

C20H22N8O2S2

Molecular Weight

470.57

References & Citations

[1]Dong S, et al. Structure Guided Discovery of Novel Pan Metallo-β-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration. J Med Chem. 2024 Feb 22.