Chlorambucil

Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease[1][2][3][4].

Product Specifications

CAS Number

[305-03-3]

Product Name Alternative

CB-1348; WR-139013

UNSPSC

12352005

Hazard Statement

H301, H315, H319, H335, H350

Target

DNA Alkylator/Crosslinker

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Chlorambucil.html

Concentration

10mM

Purity

99.84

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(O)CCCC1=CC=C(N(CCCl)CCCl)C=C1

Molecular Formula

C14H19Cl2NO2

Molecular Weight

304.21

Precautions

H301, H315, H319, H335, H350

References & Citations

[1]Guo JX, et al. Synergistic effects of chlorambucil and TRAIL on apoptosis and proliferation of Raji cells. Eur Rev Med Pharmacol Sci. 2017 Oct;21 (20) :4703-4710.|[2]Salem FS, et al. Biochemical and pathological studies on the effects of levamisole and chlorambucil on Ehrlich ascites carcinoma-bearing mice. Vet Ital. 2011 Jan-Mar;47 (1) :89-95.|[3]Mohamed D, et al. Chlorambucil-adducts in DNA analyzed at the oligonucleotide level using HPLC-ESI MS. Chem Res Toxicol. 2009;22 (8) :1435-1446.|[4]Birnbaum AD, et al. Chlorambucil and malignancy. Ophthalmology. 2010;117 (7) :1466-1466.e1.