Bergamottin

Bergamottin is a potent and competitive CYP1A1 inhibitor with a Ki of 10.703 nM.

Product Specifications

CAS Number

[7380-40-7]

Product Name Alternative

5-Geranoxypsoralen; Bergamotine; Bergaptin

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Cytochrome P450

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Bergamottin.html

Purity

99.94

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1C=CC2=C(OC/C=C(C)/CC/C=C(C)/C)C3=C(OC=C3)C=C2O1

Molecular Formula

C21H22O4

Molecular Weight

338.40

Precautions

H315, H319

References & Citations

[1]Olguín-Reyes S, et al. Bergamottin is a competitive inhibitor of CYP1A1 and is antimutagenic in the Ames test. Food Chem Toxicol. 2012 Sep;50 (9) :3094-9.|[2]Wu HJ, et al. Bergamottin isolated from Citrus bergamia exerts in vitro and in vivo antitumor activity in lung adenocarcinoma through the induction of apoptosis, cell cycle arrest, mitochondrial membrane potential loss and inhibition of cell migration and invasion. Oncol Rep. 2016 Jul;36 (1) :324-32.