Bergamottin
Product Specifications
UNSPSC Description
Bergamottin is a potent and competitive CYP1A1 inhibitor with a Ki of 10.703 nM.
Target Antigen
Cytochrome P450
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Bergamottin.html
Purity
99.97
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1C=CC2=C(OC/C=C(C)/CC/C=C(C)/C)C3=C(OC=C3)C=C2O1
Molecular Weight
338.40
References & Citations
[1]Olguín-Reyes S, et al. Bergamottin is a competitive inhibitor of CYP1A1 and is antimutagenic in the Ames test. Food Chem Toxicol. 2012 Sep;50(9):3094-9.|[2]Wu HJ, et al. Bergamottin isolated from Citrus bergamia exerts in vitro and in vivo antitumor activity in lung adenocarcinoma through the induction of apoptosis, cell cycle arrest, mitochondrial membrane potential loss and inhibition of cell migration and invasion. Oncol Rep. 2016 Jul;36(1):324-32.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N2194/Bergamottin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N2194/Bergamottin-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
7380-40-7
Available Sizes
Curated Selection
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