LM11A-31

LM11A-31, a non-peptide p75NTR (neurotrophin receptor p75) modulator, is an orally active and potent proNGF (nerve growth factor) antagonist. LM11A-31 is an amino acid derivative with high blood-brain barrier permeability and blocks p75-mediated cell death. LM11A-31 reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression[1][2].

Product Specifications

CAS Number

[102562-74-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Neurokinin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/lm11a-31.html

Concentration

10mM

Purity

99.88

Solubility

DMSO : 116.67 mg/mL (ultrasonic)

Smiles

CC[C@H](C)[C@H](N)C(NCCN1CCOCC1)=O

Molecular Formula

C12H25N3O2

Molecular Weight

243.35

Precautions

H302, H315, H319, H335

References & Citations

[1]Elshaer SL, et al. Modulation of the p75 neurotrophin receptor using LM11A-31 prevents diabetes-induced retinalvascular permeability in mice via inhibition of inflammation and the RhoA kinase pathway. Diabetologia. 2019 Aug;62 (8) :1488-1500.|[2]Simmons DA, et al. A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression. PLoS One. 2014 Aug 25;9 (8) :e102136.