7-Hydroxystaurosporine

7-Hydroxystaurosporine (UCN-01) is a synthetic derivative of Staurosporine (HY-15141) with antitumor activity. 7-hydroxystaurosporine inhibits serine/threonine kinase AKT and calcium-dependent protein kinase C activity. 7-hydroxystaurosporine also activates indirectly cyclin-dependent kinases (CDKs) . 7-hydroxystaurosporine arrests tumor cells in the G1/S of the cell cycle and prevents nucleotide excision repair by inhibiting the G2 checkpoint kinase chk1, resulting in apoptosis[1][2].

Product Specifications

CAS Number

[112953-11-4]

Product Name Alternative

UCN-01; KRX-0601

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Akt; Apoptosis; CDK; PKC

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR; TGF-beta/Smad

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/7-hydroxystaurosporine.html

Purity

97.5

Solubility

DMSO : 28 mg/mL (ultrasonic; warming)

Smiles

C[C@]12N3C4=C(C5=CC=CC=C53)C([C@H](NC6=O)O)=C6C7=C4N([C@](C[C@H]([C@H]2OC)NC)([H])O1)C8=CC=CC=C78

Molecular Formula

C28H26N4O4

Molecular Weight

482.53

Precautions

H302, H315, H319, H335

References & Citations

[1]Shao RG, et al 7-Hydroxystaurosporine (UCN-01) induces apoptosis in human colon carcinoma and leukemia cells independently of p53. Exp Cell Res. 1997 Aug 1;234 (2) :388-97.|[2]Meng QH, et al. Effect of 7-hydroxystaurosporine on glioblastoma cell invasion and migration. Acta Pharmacol Sin. 2005 Apr;26 (4) :492-9.